98% Purity Desmopressin Acetate, Pharmaceutical Peptide

• Powder: Yes
• Customized: Customized
• Certification: GMP, HSE, ISO 9001, USP, BP
• Suitable for: Adult
• State: Solid
• Purity: >98%
• Model NO.: HJYY
• appearance: White Powder
• Assay: 98%
• Water: Not More Than 5%
• Impurity: Not More Than 2%
• Acetate: Not More Than 10%
• Transport Package: 10g/Al Bag
• Specification: 95.0%~105.0%
• Trademark: HD
• Origin: China
• HS Code: 2937190090
• Production Capacity: 100000g/Month

Product Description

 

Product Description

 Desmopressin is a synthetic octapeptide, and an analogue of human hormone arginine vasopressin with antidiuretic and coagulant activities. Desmopressin binds to V2 receptors in renal collecting ducts which leads to exocytosis of von Willebrand factor (VWF) and tissue plasminogen activator (t-PA) from Weibel-Palade bodies, thereby increasing water resorption. This agent also increases NO production via activation of endothelial NO synthase, thereby induces afferent arteriolar vasodilation. Furthermore, desmopressin stimulates the release of factor VIII from endothelial cells mediated through V1a receptor, thereby promotes blood coagulation.

Product Introduction
 

Generic name	Desmopressin Acetate, Desmopressin
Synonyms	Mimirin, Octostim
Formula	C46H64N14O12S2
CAS No.	16679-58-6
Molecular Weight	1069.22
EINECS	240-726-7

  Chemical Properties

Density	1.56±0.1 g/cm3(Predicted)
Specific Rotation(α)	D25 +85.5 ± 2° (calculated for the free peptide)
Solubility	H2O: soluble20mg/mL, clear, colorless
Refractive Index	1.713
Storage Condition	Store at 0°C
pka	9.90±0.15(Predicted)
Apperance	neat

Application & Efficacy

       This product is similar in structure to the natural hormone arginine vasopressin. Acting on V1 receptor, constricting blood vessels, acting on V2 receptor, producing antidiuretic effect, its antidiuretic effect is 400 times stronger than vasopressin, but its effect on smooth muscle is weak, and the effect of pressure is weak. After use, it can reduce urine excrement, increase urine osmotic pressure, and reduce plasma Chemicalbook osmotic pressure, thus reducing frequency and nocturia. This product is absorbed from the nasal mucosa, and the bioavailability is 10% ~ 20%. Most of them are destroyed in the gastrointestinal tract after oral administration, and the bioavailability is less than 0.5%, but large doses can produce therapeutic effects. If 0.1 ~ 0.2mg is taken orally, the antidiuretic effect can be maintained for 8 ~ 12 hours.

Can be used for:

(1) Treatment of central diabetes insipidus. The drug can reduce urine discharge, reduce frequency of urination and reduce nocturia.

(2) Treatment of nocturnal enuresis (patients 5 years or older).

(3) To test the concentration function of kidney urine for differential diagnosis of renal function.

(4) for hemophilia and other Chemicalbook hemorrhagic diseases, this product can shorten the bleeding time and prevent bleeding. Can reduce the amount of intraoperative blood loss, reduce postoperative bleeding; In particular, combined with reasonably controlled intraoperative hypotension, intraoperative bleeding can be reduced from different mechanisms of action, and postoperative bleeding can be reduced, which can play a better role in blood protection. 

Detailed Photos